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Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Nonbullous pemphigoid: A systematic review.

Aniek Lamberts¹, Joost M Meijer¹, Marcel F Jonkman¹

¹University of Groningen, University Medical Center Groningen, Department of Dermatology, Center for Blistering Diseases, Groningen, The Netherlands.

Journal of the American Academy of Dermatology

|November 6, 2017

Summary

Nonbullous pemphigoid, a variant of bullous pemphigoid, often lacks blisters and mimics other itchy skin conditions. Increased physician awareness is crucial for timely diagnosis of this underrecognized autoimmune disease.

Keywords:

autoimmune blistering disease autoimmune bullous disease bullous pemphigoid characteristics clinical presentation nonbullous pemphigoid systematic review terminology

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Area of Science:

Dermatology
Autoimmune Diseases
Immunodermatology

Background:

Bullous pemphigoid is an autoimmune blistering disease characterized by tense bullae and severe pruritus.
A variant, nonbullous pemphigoid, presents without blisters, posing diagnostic challenges.

Purpose of the Study:

To summarize the clinical and diagnostic characteristics of nonbullous pemphigoid.
To highlight the need for increased physician awareness to improve diagnosis and management.

Main Methods:

A systematic literature search was conducted using EMBASE and MEDLINE databases.
Included case reports and series describing nonbullous pemphigoid, analyzing 132 cases.

Main Results:

Erythematous, urticarial plaques were the most common presentation (52.3%).
Direct and indirect immunofluorescence showed characteristic linear IgG/C3 deposition in most cases (93.2% and 90.2%, respectively).
A significant diagnostic delay of 22.6 months was observed, with few patients developing blisters later.

Conclusions:

Nonbullous pemphigoid is an underdiagnosed entity that often mimics other pruritic dermatoses.
Enhanced physician awareness is essential to reduce diagnostic delays and improve patient outcomes.