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Combination vismodegib and photodynamic therapy for multiple basal cell carcinomas
Jason M Rizzo1, Robert J Segal2, Nathalie C Zeitouni3
1Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Photodiagnosis and Photodynamic Therapy
|November 6, 2017
Summary
Combining photodynamic therapy (PDT) with vismodegib offers a safe and effective treatment for basal cell carcinoma (BCC). This combination therapy demonstrated a high response rate and good tolerability for multiple BCC lesions.
Area of Science:
- Dermatology
- Oncology
- Medical Research
Background:
- Vismodegib and photodynamic therapy (PDT) are established non-invasive treatments for basal cell carcinoma (BCC).
- Current research lacks studies on the combined efficacy of PDT and vismodegib for BCC treatment.
- Both therapies are suitable for widespread BCCs and patients unsuitable for surgery.
Purpose of the Study:
- To assess the safety and efficacy of combining red light PDT with vismodegib for multiple nodular BCCs.
- To evaluate treatment-related pain and cosmetic outcomes as secondary objectives.
Main Methods:
- An open-label pilot study involving immunocompetent patients with multiple BCCs.
- Patients received 3 months of continuous vismodegib (150 mg daily) and three consecutive ALA PDT sessions.
- Outcomes were assessed post-PDT sessions and at 30-day follow-up.
Main Results:
- Fifteen evaluable lesions showed complete responses after 3 PDT sessions; one lesion had disease at 30 days.
- The overall response rate was 90% complete response and 10% partial response.
- Combination therapy was well-tolerated, with a favorable side effect profile and excellent cosmetic results.
Conclusions:
- Combination PDT-vismodegib is a potentially safe and effective treatment for multiple BCCs.
- This combination may enhance the efficacy of individual therapies.
- The treatment demonstrated good tolerability and cosmetic outcomes.
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