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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Cell-mediated Immune Responses01:40

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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Feb 19, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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Cellular Immunotherapy for Hematologic Malignancies: Beyond Bone Marrow Transplantation.

Melita Cirillo1, Peter Tan1, Marian Sturm1

  • 1Department of Haematology Cell and Tissue Therapies, Royal Perth Hospital, Perth, Western Australia, Australia.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|November 6, 2017
PubMed
Summary

Novel cellular immunotherapies offer new hope for hematologic malignancies, providing less toxic alternatives to transplantation for relapsed or refractory patients.

Keywords:
Cellular therapyChimeric antigen receptor cellsCytokine-induced killer cellsImmunotherapyMesenchymal stromal cellsVirus-specific lymphocytes

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Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Chemotherapy is standard for hematologic malignancies, but relapse remains a major cause of mortality.
  • Novel immunotherapies aim to leverage the immune system to combat leukemia and lymphoma.

Purpose of the Study:

  • To review emerging cellular immunotherapies in hematology.
  • To discuss their potential to change treatment paradigms for hematologic malignancies.

Main Methods:

  • Review of recent advances in cellular immunotherapy for hematologic disorders.
  • Examination of specific therapies including CAR T-cells, MSCs, DC vaccines, CI K cells, and VS T cells.

Main Results:

  • Cellular immunotherapy is rapidly evolving for high-risk hematologic disorders.
  • Nontransplantation cellular immunotherapy offers alternatives for patients unsuitable for or failed by transplantation.
  • These therapies may provide a less toxic treatment option compared to transplantation.

Conclusions:

  • Emerging cellular immunotherapies are transforming treatment approaches for hematologic malignancies.
  • These innovative therapies hold promise for improving outcomes in relapsed/refractory patients.