Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of 4-methylpyrazole on ethanol-induced decrease in rat plasma amino acids.

M Hagman1, R Jagenburg

  • 1Department of Clinical Chemistry, Gothenburg University, Sahlgren's Hospital, Sweden.

Biochemical Pharmacology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of operational conditions and wastewater properties on the removal of organic micropollutants through ozonation.

Journal of environmental management·2021
Same author

Is dissolved COD a suitable design parameter for ozone oxidation of organic micropollutants in wastewater?

The Science of the total environment·2018
Same author

Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity.

European journal of applied physiology·2017
Same author

Repeated evolution of exaggerated dewlaps and other throat morphology in lizards.

Journal of evolutionary biology·2015
Same author

Investigation of different cell types and gel carriers for cell-based intervertebral disc therapy, in vitro and in vivo studies.

Journal of tissue engineering and regenerative medicine·2011
Same author

Fitness disadvantages to disrupted embryogenesis impose selection against suboptimal nest-site choice by female grass snakes, Natrix natrix (Colubridae).

Journal of evolutionary biology·2010

Ethanol consumption rapidly lowers plasma amino acids. This study reveals that ethanol oxidation, not just hormonal responses, significantly contributes to this amino acid depletion in rats.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Physiology

Background:

  • Acute ethanol intake reduces plasma amino acid concentrations.
  • Previous research implicated beta-adrenergic and adrenocortical pathways in this effect.

Purpose of the Study:

  • To investigate the role of ethanol oxidation in ethanol-induced plasma amino acid decrease.
  • To determine if inhibiting ethanol metabolism alters the effect on amino acids.

Main Methods:

  • Male rats were administered 4-methylpyrazole, a liver alcohol dehydrogenase inhibitor.
  • This inhibition significantly reduced ethanol elimination (85%).
  • Plasma amino acid levels were compared between treated and control groups.

Main Results:

Related Experiment Videos

  • Rats pretreated with 4-methylpyrazole showed a less pronounced decrease in plasma amino acids after ethanol administration.
  • Inhibition of ethanol oxidation significantly attenuated the amino acid-lowering effect of ethanol.

Conclusions:

  • Ethanol oxidation plays a significant role in the acute decrease of plasma amino acids.
  • The metabolic process of ethanol breakdown contributes to amino acid depletion, alongside hormonal mechanisms.