Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.4K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
Glaucoma: Overview01:25

Glaucoma: Overview

1.5K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlling nitrosamine accumulation in dry fermented sausages using Lacticaseibacillus rhamnosus H7: The role of physicochemical drivers and precursor depletion.

Food microbiology·2026
Same author

Salinity-driven microbial adaptation of hydrocarbon-degrading communities in coastal sediments.

mSphere·2026
Same author

Surficial Au-S Bond Energy Repetitively Exciting Gold Nanoparticles for Enhanced Chemiluminescence Photons per Luminophore and Automatic Single-Molecule Immunoassay.

Analytical chemistry·2026
Same author

Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma.

Clinical chemistry·2026
Same author

Integrated prediction of ceftriaxone resistance in major Salmonella serotypes using MALDI-TOF MS data with balanced datasets and machine learning.

International journal of antimicrobial agents·2026
Same author

Quantifying the Contribution of Cryptic Sulfide-Driven Autotrophic Denitrification to N<sub>2</sub>O Production in a Seasonally Hypoxic River-Reservoir System.

Environmental science & technology·2026

Related Experiment Video

Updated: Feb 19, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.9K

Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective

Shengjie Li1, Yanting Gao1, Mingxi Shao1

  • 1Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

BMJ Open
|November 6, 2017
PubMed
Summary

Patients with primary angle closure glaucoma (PACG) exhibit shorter coagulation times. This study suggests that coagulation function plays a significant role in the development of PACG.

Keywords:
Case-control StudyCoagulation FunctionPrimary Angle Closure Glaucoma

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

Related Experiment Videos

Last Updated: Feb 19, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.9K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

Area of Science:

  • Ophthalmology
  • Hematology
  • Medical Research

Background:

  • Primary angle closure glaucoma (PACG) is a significant cause of irreversible blindness worldwide.
  • Understanding the factors contributing to PACG pathogenesis is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To investigate the association between coagulation function and the presence of primary angle closure glaucoma (PACG).

Main Methods:

  • A retrospective case-control study was conducted with 1778 participants (PACG patients and controls).
  • Coagulation parameters including activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time, D-dimer, and mean platelet volume (MPV) were analyzed.
  • Multivariate logistic regression identified independent risk factors for PACG.

Main Results:

  • Patients with PACG showed significantly shorter APTT, PT, and thrombin times compared to controls.
  • Elevated D-dimer and mean platelet volume (MPV) levels were observed in the PACG group.
  • APTT, PT, and MPV were identified as independent risk factors associated with PACG.

Conclusions:

  • PACG patients demonstrate altered coagulation profiles, characterized by shorter clotting times.
  • Coagulation function is significantly associated with PACG and may be implicated in its onset and progression.