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An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
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DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells

Ken Takasawa1, Yoshikazu Arai1, Mayu Yamazaki-Inoue2

  • 1Laboratory of Veterinary Biochemistry and Molecular Biology, Graduate School of Medicine and Veterinary Medicine/Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai-Nishi, Miyazaki, 889-2192, Japan.

Human Cell
|November 6, 2017
PubMed
Summary

DNA methylation regulates TERT gene expression during induced pluripotent stem cell (iPSC) reprogramming. A specific TERT promoter region becomes methylated in iPSCs, enhancing TERT transcription and gene expression.

Keywords:
DNA methylationEpigeneticsHuman TERT geneHuman iPSCsLamin B1Reprogramming

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