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Allergic Reactions

Allergic Reactions

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Related Experiment Video

Updated: Feb 19, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Rational Approach to Allergy Testing.

Michael P Platt¹, Jacqueline A Wulu¹

¹Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Boston, MA 02118, USA.

Otolaryngologic Clinics of North America

|November 7, 2017

Summary

This summary is machine-generated.

Allergy testing, including skin tests and serum IgE tests, helps manage allergic rhinitis when symptoms persist. Choosing the best allergy test depends on individual history and patient choice.

Keywords:

Allergic sensitization Allergy testing Intradermal In vitro testing Skin prick Skin testing

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Last Updated: Feb 19, 2026

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Immunology
Allergology

Background:

Allergic rhinitis symptoms often necessitate allergy testing for effective management.
Treatment options like allergen avoidance and immunotherapy depend on accurate diagnosis.

Purpose of the Study:

To outline the common methods of allergy testing.
To discuss the factors influencing the choice between in vivo and in vitro allergy testing.
To emphasize the importance of understanding the benefits and limitations of each testing method.

Main Methods:

In vivo allergy testing: prick/puncture and intradermal skin tests.
In vitro allergy testing: measurement of serum-specific IgE.
Clinical history evaluation to guide testing selection.

Main Results:

Both skin testing and serum-specific IgE testing are utilized for diagnosing allergic conditions.
The selection of testing modality is influenced by clinical presentation and patient factors.
No single allergy test is universally superior; each has distinct advantages and disadvantages.

Conclusions:

Informed patient and physician decision-making is crucial for selecting the optimal allergy testing strategy.
Understanding the nuances of different allergy tests improves patient care for allergic rhinitis.
Personalized approach to allergy testing ensures the most effective management plan.