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Published on: March 31, 2023
High ALDH1A1 expression indicates a poor prognosis in gastric neuroendocrine carcinoma
Yuhong Ye1, Sheng Zhang1, Yupeng Chen1
1Department of Pathology, The First Affiliated Hospital of Fujian Medical University, 350005 Fuzhou, China.
Objective:
To evaluate the expression and prognostic significance of ALDH1A1 in gastric neuroendocrine carcinoma.
Materials And Methods:
Immunohistochemical stains of ALDH1A1 were evaluated in 67 cases of gastric neuroendocrine carcinoma. The findings were correlated with clinicopathologic variables and overall survival.
Results:
Immunohistochemistry revealed positive cytoplasmic immunoreactivity in 35 of 67 (52.2%) tumors and strongly positive immunoreactivity in 14 of 67 (20.9%). Strongly positive ALDH1A1 expression, but not positive staining, was significantly associated with lymph node status, lymphovascular invasion, and ki-67 index (P=0.039, 0.045, and 0.045, respectively). Kaplan-Meier survival curves and log-rank tests showed significantly poorer prognoses in cases of high ALDH1A1 expression compared to cases of low ALDH1A1 expression or the negative control group (MST, 17 vs. 52 months; P=0.026). Multivariate analysis showed that high ALDH1A1 expression, lymph node metastasis, and lymphovascular invasion had significant associations with decreased overall survival (P=0.029, 0.008, and 0.005, respectively).
Conclusions:
High ALDH1A1 expression may be a prognostic indicator of survival in patients with gastric neuroendocrine carcinoma.
