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Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with

Lei Zhang1, Chao Chen2, Nan Zhou3

  • 1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, Jiangsu, China; Department of Endocrinology and Metabolism, Xinghua People's Hospital, 419 Yingwu Road, Xinghua 225700, Jiangsu, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 7, 2017
PubMed
Abstract

Insights

Serum asprosin levels are elevated in adults with type 2 diabetes mellitus (T2DM). Asprosin may be a risk factor for T2DM, but it is not an ideal predictive biomarker.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Research

Background:

  • Asprosin, a novel hormone from white adipose tissue, is elevated in insulin resistance.
  • Its role in type 2 diabetes mellitus (T2DM) requires further investigation.

Purpose of the Study:

  • To investigate the association between circulating asprosin concentrations and T2DM in adults.
  • To determine if asprosin could serve as a biomarker for T2DM.

Main Methods:

  • A hospital-based study involving 84 adults with T2DM and 86 healthy controls.
  • Serum asprosin levels measured using ELISA.
  • Statistical analyses included logistic regression and ROC curve analysis.

Main Results:

  • Serum asprosin concentrations were significantly higher in T2DM patients compared to controls (P<0.001).
  • Higher asprosin levels correlated with an increased prevalence of T2DM.
  • Asprosin showed moderate predictive value for T2DM (AUC=0.707).

Conclusions:

  • Elevated serum asprosin is observed in adults with T2DM.
  • Asprosin may be implicated in T2DM pathogenesis and could be a risk factor.
  • Asprosin is not considered an ideal biomarker for predicting T2DM.
Keywords:
AdipokineAsprosinInsulin resistanceType 2 diabetes mellitusWhite adipose tissue

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