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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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High TREM2 expression correlates with poor prognosis in gastric cancer

Xiaojing Zhang1, Wei Wang2, Peng Li3

  • 1Department of Clinical Bio-bank, Nantong University Affiliated Hospital, Nantong, Jiangsu 226001, China; Department of Pathology, Medical School of Nantong University, Nantong, Jiangsu 226001, China.

Human Pathology
|November 7, 2017
PubMed

Insights

Triggering receptor expressed on myeloid cells 2 (TREM2) is elevated in gastric cancer tissues. Higher TREM2 expression correlates with advanced disease stages and poorer patient prognosis, suggesting its potential as a biomarker.

Area of Science:

  • Immunology
  • Oncology

Background:

  • Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin superfamily member.
  • TREM2 forms a signaling complex with TYRO protein tyrosine kinase-binding protein at the cell membrane.
  • Gastric cancer (GC) is a prevalent and significant global health concern.

Purpose of the Study:

  • To quantify TREM2 protein and mRNA expression in GC tissues.
  • To assess the prognostic value of TREM2 in GC patients.

Main Methods:

  • Analysis of 317 GC tissue samples, adjacent normal tissues, and benign gastric lesions.
  • Quantitative real-time polymerase chain reaction (qRT-PCR) for mRNA expression.
  • Immunohistochemistry (IHC) for protein expression.
  • Utilized Oncomine and Kaplan-Meier Plotter for data analysis.

Main Results:

  • TREM2 mRNA and protein levels were significantly higher in GC tissues compared to normal gastric tissues (P<.0001 and P<.001, respectively).
  • High TREM2 expression was significantly associated with poor differentiation (P<.05), advanced N stage (P<.001), and TNM stage (P<.001).
  • TREM2 expression levels showed an inverse correlation with patient prognosis.

Conclusions:

  • TREM2 is upregulated in gastric cancer.
  • TREM2 expression serves as a potential prognostic biomarker for gastric cancer.
Keywords:
Gastric cancerPrognosisProtein expressionTREM2mRNA expression

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