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Heck-like Reactions Involving Heteroatomic Electrophiles
Bojan Vulovic1, Donald A Watson1
1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA, dawatson@udel.edu.
European Journal of Organic Chemistry
|November 7, 2017
Summary
Heteroatomic-Heck reactions offer flexible synthetic routes using non-carbon electrophiles. This review covers early developments, current advancements, and related processes in this emerging area of organic chemistry.
Area of Science:
- Synthetic Organic Chemistry
- Organometallic Chemistry
Background:
- The Heck reaction, discovered in the 1970s, is a cornerstone of synthetic organic chemistry.
- Traditional Heck reactions utilize carbon electrophiles.
- Recent advancements explore the use of heteroatomic electrophiles, expanding the reaction's scope and utility.
Purpose of the Study:
- To review the early developments and current state of heteroatomic-Heck reactions.
- To highlight the synthetic flexibility and applications of these reactions.
- To discuss related emerging processes in organometallic chemistry.
Main Methods:
- Literature review of early and recent studies on heteroatomic-Heck reactions.
- Analysis of key developments in silyl-Heck, boryl-Heck, and intramolecular aza-Heck reactions.
- Exploration of related synthetic methodologies.
Main Results:
- Heteroatomic-Heck reactions provide novel pathways to valuable synthetic precursors.
- These reactions enable access to structural motifs found in biologically active compounds.
- The flexibility of heteroatomic electrophiles significantly broadens the Heck reaction's applicability.
Conclusions:
- Heteroatomic-Heck reactions represent a significant and evolving area within synthetic organic chemistry.
- These reactions offer powerful new tools for constructing complex molecules.
- Continued research promises further expansion of their synthetic utility and biological relevance.
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