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Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
Published on: May 12, 2019
In a Heartbeat: Light and Cardiovascular Physiology
Sarah L Chellappa1,2, Ruta Lasauskaite3, Christian Cajochen3
1Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States.
Morning light exposure influences cardiovascular function by increasing sympathetic tone. Dynamic light in the early morning may mitigate negative sleep-to-wake transitions, highlighting light
Area of Science:
- Chronobiology
- Cardiovascular Physiology
- Ophthalmology
Background:
- Light exposure impacts vision and regulates the body's internal circadian timing system.
- The suprachiasmatic nuclei (circadian pacemaker) influence cardiovascular function and exhibit daily rhythms.
- Adverse cardiovascular events often follow a circadian pattern.
Purpose of the Study:
- To investigate the potential effects of light exposure on cardiovascular function.
- To review existing research on the relationship between light and cardiovascular health.
Main Methods:
- Review and synthesis of existing research findings on light exposure and cardiovascular parameters.
- Analysis of time-of-day dependent effects of light, including bright and dynamic light exposure.
- Consideration of various light parameters like illuminance and wavelength.
Main Results:
- Bright light exposure in the morning, but not evening, is associated with increased relative sympathetic tone.
- Dynamic light during early morning hours can reduce adverse cardiac modulation during the sleep-to-wake transition.
- Research findings on the effects of specific light parameters (illuminance, monochromatic wavelength) on cardiac function are inconsistent.
Conclusions:
- Light exposure, particularly in the morning, can modulate cardiovascular function.
- Timing, duration, and wavelength composition of light are critical factors to consider.
- Light presents a potential non-invasive strategy for managing cardiovascular events.
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