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Updated: Feb 19, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Multiple Primary Acral Lentiginous Melanomas (MPALM)
Miriam González1, Georgi Tchernev2,3, Anastasiya Atanasova-Chokoeva3
1Department of Internal Medicine, Autonomous University of Honduras (UNAH), Service of Dermatology and Dermatologic Surgery, School University Hospital (HEU), Tegucigalpa 11101, Honduras.
Abstract:
We present a rare case of a patient with multiple primary acral lentiginous melanomas of the foot. We would like to highlight the importance of whole-skin examination in all patients, even by the general practitioners, aiming the maximal early detection of acral lentiginous melanomas, considering their rapid progression, early metastatic spread and extremely poor prognosis. It can be extrapolated from current literature; however, that appropriate management of these patients, including staging work and surgical intervention, is to be determined by the individual characteristics of the melanoma and the patient's concomitant risk factors, if any.

