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Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles

Eudald Casals1, Muriel F Gusta1, Macarena Cobaleda-Siles1

  • 1Vall d'Hebron Research Institute (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

Cancer Nanotechnology
|November 7, 2017
PubMed

Insights

Nanoparticle-based platforms offer a promising strategy to overcome anticancer drug resistance by enabling multimodal therapies. Further understanding of nanoparticle behavior in biological environments is crucial for clinical application.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Chemotherapeutic agents face limitations due to drug resistance, impacting cancer cure capabilities.
  • Cancer drug resistance arises from patient variability and tumor genetic heterogeneity.
  • Multimodality presents a promising strategy to surmount treatment resistance.

Purpose of the Study:

  • To review cancer resistance mechanisms.
  • To highlight the advantages of inorganic nanomaterials in enabling multimodality against cancer resistance.
  • To discuss the necessity of understanding nanoparticle-biological interactions for therapeutic advancement.

Main Methods:

  • Literature review of cancer resistance mechanisms.
  • Analysis of inorganic nanomaterials for multimodal cancer therapy applications.
  • Discussion on nanoparticle-biological environment interactions.

Main Results:

  • Nanoparticle-based platforms can address cancer resistance through various mechanisms.
  • Inorganic nanomaterials offer advantages for multimodal therapies, including drug delivery, imaging, and radiotherapy.
  • Nanoparticles can function as carriers, imaging agents, and therapeutic effectors.

Conclusions:

  • Nanoparticle-based platforms are crucial for developing advanced multimodal cancer therapies.
  • Overcoming cancer resistance requires a comprehensive understanding of nanomaterial behavior in vivo.
  • Further research into nanoparticle-biological interactions is essential for realizing their full therapeutic potential.
Keywords:
Cancer resistanceInorganic nanoparticlesMultifunctionalMultimodalityResistance to treatment

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