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Risk factors for asthma after infant bronchiolitis
S Törmänen1, E Lauhkonen1, R Riikonen1
1Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Allergy
|November 7, 2017
Summary
Infants hospitalized for bronchiolitis have double the risk of developing asthma later in childhood. Maternal asthma is the primary early-life risk factor identified for childhood asthma development.
Area of Science:
- Pediatric Pulmonology
- Epidemiology
- Allergy & Immunology
Background:
- Bronchiolitis in infancy is a significant risk factor for later respiratory issues.
- Previous studies identified several early-life risk factors for asthma post-bronchiolitis.
- This study focuses on the long-term asthma outcomes in children previously hospitalized for bronchiolitis.
Purpose of the Study:
- To evaluate the long-term respiratory health outcomes, specifically doctor-diagnosed asthma, in children up to 11-13 years of age.
- To identify significant early-life risk factors for the development of asthma after infant bronchiolitis.
Main Methods:
- Prospective follow-up of 138 children previously hospitalized for bronchiolitis before 6 months of age.
- Data collection included questionnaires, parental interviews, clinical examinations, and bronchodilation testing at 11-13 years of age.
Main Results:
- Doctor-diagnosed asthma was present in 13% of former bronchiolitis patients at 11-13 years.
- Maternal asthma was the sole significant independent early-life risk factor (aOR 3.45).
- Allergic rhinitis at 5-7 years was also a significant risk factor (aOR 4.06).
Conclusions:
- Children hospitalized for bronchiolitis before 6 months of age have approximately double the risk of developing asthma compared to the general population.
- Maternal asthma is the most critical independently significant early-life predictor of developing asthma by adolescence.
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