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Role of microRNA-155 in rheumatoid arthritis

Lin-Chong Su1,2, An-Fang Huang3, Hong Jia4

  • 1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan.

International Journal of Rheumatic Diseases
|November 7, 2017
PubMed

Insights

MicroRNA-155 (miR-155) is elevated in rheumatoid arthritis (RA) and drives immune responses in autoimmune arthritis. Understanding miR-155 mechanisms may lead to new RA therapies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are post-transcriptional regulators affecting gene expression.
  • miRNA-155 (miR-155) plays a key role in immune cell regulation.
  • Elevated miR-155 expression is implicated in rheumatoid arthritis (RA) pathogenesis.

Purpose of the Study:

  • To review recent findings on miR-155 in immune responses.
  • To summarize mechanisms of miR-155 in autoimmune arthritis.
  • To explore potential therapeutic strategies targeting miR-155.

Main Methods:

  • Literature review of recent studies on miR-155 and autoimmune arthritis.
  • Analysis of molecular mechanisms underlying miR-155's role in immune cells.
  • Synthesis of data on miR-155 expression levels in RA patients and models.

Main Results:

  • miR-155 is significantly upregulated in RA patients and arthritis models.
  • Modulation of miR-155 (overexpression or knockdown) impacts arthritis development.
  • miR-155 influences immune cell function critical to RA pathogenesis.

Conclusions:

  • miR-155 is a crucial regulator in the immune response underlying autoimmune arthritis.
  • Understanding miR-155's mechanisms offers insights into RA pathogenesis.
  • Targeting miR-155 presents a potential avenue for novel RA therapeutic strategies.
Keywords:
autoimmunitymicroRNA-155rheumatoid arthritis

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