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Genome-based analysis of virulence determinants of a Serratia marcescens strain from soft tissues following a snake
Yao-Ting Huang1, Jan-Fang Cheng2, Yi-Ting Liu1
1Department of Computer Science & Information Engineering, National Chung Cheng University, Chia-Yi, Taiwan.
Aim:
Serratia marcescens wound infection after snakebite is often associated with aggressive presentations. However, the virulence determinants remain understudied.
Materials & Methods:
Whole-genome sequencing was performed on S. marcescens VGH107, an isolate from wound infection secondary to Trimeresurus mucrosquamatus bite. Comparative genomics approach coupled with multivirulent-locus sequencing typing was applied to systematically predict potential virulence factors.
Results:
Multivirulent-locus sequencing typing indicated VGH107 falls within the cluster of high pathogenic strains. Comparative analysis identified virulence genes unique in VGH107, including ecpD and ecpE genes for periplasmic chaperone-pilus subunit complex and cdiA and cdiB genes for contact-dependent growth inhibition system.
Conclusion:
The data established here provide foundation for further research regarding the virulence and resistance of S. marcescens.
