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Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
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Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
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Focus on aggressive behaviour in mental illness.

Enrico Pompili1, Cristiano Carlone2, Cristiana Silvestrini1

  • 1Department of Mental Health Colleferro, ASL Roma G, Italy.

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Summary
This summary is machine-generated.

Aggression in mental illness is a major public health concern. Understanding its neurobiology offers new pathways for targeted treatments and improved patient outcomes.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Aggression is a destructive behavior with evolutionary roots, often maladaptive in modern society.
  • Increased aggressive behavior is a clinical challenge in serious mental illnesses, leading to violence, public health concerns, and increased healthcare costs.
  • Aggression contributes to psychiatric hospitalizations, prolonged stays, patient/victim suffering, and stigmatization.

Purpose of the Study:

  • To review and summarize the neurobiological basis and therapeutic interventions for aggressive behavior in psychiatric disorders.
  • To analyze pertinent literature from 2010-2016 focusing on aggression and mental illness.

Main Methods:

  • Selective literature search on PubMed (2010-2016).
  • Analysis and synthesis of information from original articles, reviews, and book chapters.
  • Discussion of neurobiological underpinnings and treatment strategies for aggression.

Main Results:

  • The neurobiology of aggression presents a significant challenge, with heterogeneity complicating causal understanding.
  • Identification of specific aggression subtypes offers potential for individualized treatment approaches.
  • Neuroimaging studies are crucial for understanding the link between neurocognition, personality, and violent behavior.

Conclusions:

  • Advances in understanding the neurobiology of aggression can improve clinical diagnostics and therapeutic interventions.
  • Neurobehavioral targets are emerging for treatments including cognitive, pharmacological, and neuromodulatory approaches.
  • New insights into aggression's neurobiology promise novel avenues for treating this costly and destructive behavior.