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Updated: Feb 19, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Simultaneous transcatheter transfemoral aortic and transeptal mitral valve replacement using Edward SAPIEN S3
Zaher Fanari1,2, Hadi Mahmaljy3, Shalish Nandish1
1Division of Cardiology, Prairie Heart Institute, Springfield, Illinois.
Insights
Transcatheter aortic valve replacement (TAVR) and transcatheter mitral valve replacement (TMVR) offer a feasible, minimally invasive treatment for elderly patients with severe aortic and mitral stenosis. This combined approach significantly improved symptoms in a high-risk patient.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Valvular Heart Disease
Background:
- Elderly patients with severe aortic stenosis (AS) and severe mitral stenosis (MS) often have comorbidities, increasing surgical risk.
- Severe mitral annular calcification (MAC) complicates treatment options for severe mitral stenosis.
- Transcatheter mitral valve replacement (TMVR) presents an alternative for high-risk patients with severe MS and MAC.
Observation:
- A case report details an 83-year-old male with symptomatic severe AS and severe native MS with severe MAC.
- The patient had a high Society of Thoracic Surgeons (STS) score, indicating elevated surgical risk.
- He also had moderate mitral regurgitation.
Findings:
- A simultaneous transfemoral TAVR and transseptal TMVR procedure was successfully performed.
- The combined transcatheter approach was feasible and minimally invasive.
- The patient experienced significant symptom improvement post-procedure, sustained at 10-month follow-up.
Implications:
- Simultaneous TAVR and transseptal TMVR is a viable treatment strategy for complex valvular heart disease.
- This combined approach offers a less invasive option for high-risk elderly patients.
- The findings suggest potential for improved outcomes and quality of life in this challenging patient population.
Abstract:
Patients with concomitant severe aortic stenosis (AS) and severe mitral stenosis (MS) with mitral annular calcification (MAC) constitute an elderly high-risk population with multiple baseline comorbidities that coexist even before they develop severe valvular dysfunction. Transcatheter mitral valve replacements (TMVR) offer an alternative option for high-risk patient with severe MS with MAC. A simultaneous transfemoral Transcatheter aortic valve replacement (TAVR) and transseptal TMVR is feasible and offers the least invasive approach of management. We are reporting a case of an 83-year-old man with very symptomatic severe AS and severe native MS with associated severe MAC and moderate mitral regurgitation with high STS score who underwent a simultaneous transfemoral TAVR and transseptal TMVR with good results and great improvement in symptoms that was maintained on 10 months follow-up.
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