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Updated: Feb 19, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
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Calcium signalling links MYC to NUAK1

T Monteverde1, J Tait-Mulder1, A Hedley2

  • 1Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK.

Oncogene
|November 7, 2017
PubMed
Summary

NUAK1 kinase activity is maintained by calcium and PKCα in LKB1-deficient tumor cells, protecting them from MYC-driven death. This reveals a novel role for calcium in tumor cell survival and the NUAK1-MYC synthetic lethal interaction.

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