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Related Experiment Video

Updated: Feb 19, 2026

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
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Cancer risk in children born after donor ART.

C L Williams1, K J Bunch2, M F G Murphy3

  • 1University College London, Great Ormond Street Institute of Child Health, London WC1 1EH, UK.

Human Reproduction (Oxford, England)
|November 7, 2017
PubMed
Summary

Children born after donor assisted reproductive technology (ART) do not have an increased risk of childhood cancer. A small increased risk of hepatoblastoma was observed, linked to low birth weight, but overall cancer risks remain very low.

Keywords:
ARTchildhood cancercohort studydata linkagedonor treatmentepidemiology

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Area of Science:

  • Reproductive Medicine
  • Pediatric Oncology
  • Epidemiology

Background:

  • Population-based studies indicate no increased overall childhood cancer risk after non-donor assisted reproductive technology (ART).
  • Previous research has suggested potential small increases in specific cancer types, such as hematological cancers.
  • Cancer risk in children conceived via donor ART has not been previously investigated.

Purpose of the Study:

  • To investigate the risk of childhood cancer in individuals conceived after donor ART.
  • To compare cancer incidence in donor ART-conceived children with the general population.

Main Methods:

  • A retrospective cohort study linked records of 12,137 children born after donor ART in Great Britain (1992-2008) to the UK National Registry of Childhood Tumours.
  • Cancer incidence was compared to age, sex, and calendar year standardized population rates.
  • Stratification was used to explore potential mediating factors like birth weight and multiple births.

Main Results:

  • No overall increased risk of childhood cancer was identified in the donor ART cohort (12 observed vs. 14.4 expected cases; SIR 0.83).
  • A small, statistically significant increased risk of hepatoblastoma was observed (SIR 10.28), associated with low birth weight.
  • The absolute number of cases and risks for specific cancers, including hepatoblastoma, were very small.

Conclusions:

  • This study provides reassurance regarding the overall risk of childhood cancer for individuals born after donor ART.
  • A slight increase in hepatoblastoma risk, linked to low birth weight, was detected but involves very small absolute risks.
  • Further research with longer follow-up is warranted to fully understand long-term outcomes.