TCMID 2.0: a comprehensive resource for TCM.

Area of Science:

• Pharmacology
• Bioinformatics
• Traditional Chinese Medicine (TCM) research

Background:

• TCM is gaining global recognition in life sciences.
• The TCM Integrated Database (TCMID) was established for TCM modernization and standardization.
• Previous versions were highly valued by researchers.

Purpose of the Study:

• To update and expand the TCMID with new data.
• To include chemical changes during decocting and mass spectrometry data.
• To facilitate TCM modernization and explore its biological mechanisms.

Main Methods:

• Data collection on herbal ingredients, prescriptions, targets, drugs, and diseases.
• Inclusion of new data on prescription ingredients and their chemical changes.
• Addition of herbal and ingredient mass spectrometry (MS) spectra for quality control and identification.

Main Results:

• TCMID 2.0 includes 18,203 herbal ingredients, 15 prescriptions, 82 targets, 1356 drugs, and 842 diseases.
• 778 herbal MS spectra and 3895 ingredient MS spectra were added.
• New connections between TCM components and biological entities were established.

Conclusions:

• TCMID 2.0 represents a significant expansion of TCM data.
• The updated database will advance TCM standardization and research.
• It will aid in understanding the biological basis of TCM's therapeutic effects.