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MSDD: a manually curated database of experimentally supported associations among miRNAs, SNPs and human diseases

Ming Yue1, Dianshuang Zhou1, Hui Zhi1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.

Nucleic Acids Research
|November 7, 2017
PubMed

Insights

The MiRNA SNP Disease Database (MSDD) is a new resource detailing links between microRNAs (miRNAs), genetic variations called single nucleotide polymorphisms (SNPs), and human diseases. This database aids in understanding how these genetic changes impact disease development.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Single nucleotide polymorphisms (SNPs) in microRNA (miRNA)-related regions, termed miRSNPs, can disrupt miRNA function and gene regulation.
  • This dysregulation is implicated in the susceptibility to and onset of various human diseases.
  • A comprehensive resource is needed to consolidate known miRSNP-disease associations.

Purpose of the Study:

  • To describe the MiRNA SNP Disease Database (MSDD).
  • To provide a manually curated collection of experimentally supported associations between miRNAs, SNPs, and human diseases.
  • To facilitate research into the role of miRSNPs in disease.

Main Methods:

  • Manual curation of over 2000 published papers.
  • Systematic collection of data on miRNA, SNP, gene, and disease associations.
  • Inclusion of details on SNP location, alleles, miRNA dysfunction, experimental methods, and functional descriptions.

Main Results:

  • The MSDD currently documents 525 associations involving 182 miRNAs, 197 SNPs, 153 genes, and 164 diseases.
  • Each record includes comprehensive information on the molecular players, genetic variations, and disease context.
  • The database offers a user-friendly interface for data browsing, retrieval, download, and submission.

Conclusions:

  • MSDD serves as a valuable resource for understanding miRNA dysfunction in human diseases.
  • The database aids in elucidating the mechanisms by which miRSNPs contribute to disease pathogenesis.
  • MSDD has the potential to advance research in miRNA-related disease and personalized medicine.

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