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Related Experiment Video

Updated: Feb 19, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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[Left atrial appendage closure and embolic events].

M Akodad1, P Garot1

  • 1Service Angio, institut cardiovasculaire Paris-Sud (ICPS), hôpital Jacques Cartier, Ramsay-Generale de santé, Massy, France.

Annales De Cardiologie Et D'Angeiologie
|November 7, 2017
PubMed
Summary

Left atrial appendage closure shows non-inferiority to anticoagulation for preventing embolic events in atrial fibrillation. Further research is needed comparing it to direct oral anticoagulants and assessing cost-effectiveness.

Keywords:
Accident vasculaire cérébralAnticoagulationAtrial fibrillationBleeding eventsFermeture d’auricule gaucheFibrillation atrialeLeft atrial appendage closureStrokeÉvènements hémorragiques

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Area of Science:

  • Cardiology
  • Medical Devices
  • Preventive Medicine

Background:

  • Atrial fibrillation (AF) frequently causes embolic events.
  • Anticoagulant therapy (VKA, DOAC) is standard for AF stroke prevention.
  • Left atrial appendage closure (LAAC) is an emerging alternative for high-risk patients.

Purpose of the Study:

  • To evaluate LAAC as an alternative to anticoagulation in nonvalvular AF.
  • To compare the efficacy and safety of LAAC versus VKA.
  • To explore potential expanded indications for LAAC.

Main Methods:

  • Analysis of randomized trial data comparing LAAC to VKA.
  • Assessment of procedural improvements and complication rates for LAAC.
  • Review of current literature on LAAC versus direct oral anticoagulants (DOACs).

Main Results:

  • LAAC demonstrated non-inferiority to VKA regarding stroke and cardiovascular death.
  • LAAC procedures show improved safety and reduced complications.
  • Anticoagulation poses risks of hemorrhage and adherence challenges in asymptomatic patients.

Conclusions:

  • LAAC is a viable alternative to VKA for stroke prevention in nonvalvular AF.
  • LAAC may be considered for lower-risk patients due to anticoagulation risks.
  • More data is needed on LAAC versus DOACs and its cost-effectiveness.