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Related Experiment Video

Updated: Feb 19, 2026

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

GABA_B receptor subtypes differentially regulate thalamic spindle oscillations.

Daniel Ulrich¹, Txomin Lalanne¹, Martin Gassmann¹

¹Dept. Biomedicine, Institute of Physiology, University of Basel, 4056 Basel, Switzerland.

Neuropharmacology

|November 7, 2017

Summary

This summary is machine-generated.

This study reveals how different GABA_B receptor subtypes and auxiliary KCTD16 subunits precisely control thalamic spindle oscillation strength and frequency. Understanding these GABA_B receptor roles is key for brain network function.

Keywords:

Epilepsy GPCR KCTD12 KCTD16 Sleep

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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Area of Science:

Neuroscience
Molecular Biology
Neuropharmacology

Background:

GABA_B receptors are crucial for neuronal inhibition and brain oscillations.
These receptors form distinct heterodimers (GABA_B(1a,2) and GABA_B(1b,2)) with auxiliary KCTD subunits.
GABA_B receptors are implicated in thalamic spindle oscillations, essential for cognitive functions.

Purpose of the Study:

To elucidate the specific roles of GABA_B(1a,2) and GABA_B(1b,2) receptor subtypes in regulating thalamic spindle oscillations.
To investigate the contribution of the auxiliary KCTD16 subunit in modulating these network activities.

Main Methods:

Utilized knock-out mouse models lacking specific GABA_B receptor subunits.
Employed electrical and optogenetic stimulation to induce thalamic spindle oscillations.
Conducted pharmacological experiments on acute brain slices.

Main Results:

GABA_B(1a,2) heteroreceptors at thalamocortical relay (TCR) to thalamic reticular nucleus (TRN) synapses regulate oscillation strength.
GABA_B(1b,2) receptors control the frequency of thalamic spindle oscillations.
The auxiliary KCTD16 subunit influences both oscillation strength and frequency, acting through both receptor subtypes.

Conclusions:

Distinct GABA_B receptor heterodimers differentially regulate thalamic spindle oscillation parameters.
The auxiliary KCTD16 subunit plays a significant role in fine-tuning network activity via GABA_B receptors.
Findings provide critical insights into the molecular mechanisms governing brain oscillations and neuronal network function.