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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Hedgehog signalling in liver pathophysiology.

Mariana Verdelho Machado1, Anna Mae Diehl2

  • 1Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA; Gastroenterology Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.

Journal of Hepatology
|November 7, 2017
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Summary

Chronic liver disease, including fatty liver, is a growing global health crisis. Targeting the Hedgehog pathway shows promise for developing new therapies to prevent and reverse liver cirrhosis.

Keywords:
Hedgehog pathwayLiver diseaseWound healing response

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Area of Science:

  • Hepatology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Liver disease is a major global health concern, with rising rates of chronic fatty liver disease due to alcohol and obesity.
  • Cirrhosis develops in approximately 20% of individuals with chronic liver injury, necessitating urgent therapeutic strategies.
  • Current medical therapies for chronic fatty liver disease are limited, highlighting the need for novel treatment approaches.

Purpose of the Study:

  • To review the role of the Hedgehog signaling pathway in liver disease progression.
  • To explore the potential of modulating the Hedgehog pathway for therapeutic benefit in liver injury.
  • To understand the mechanisms controlling liver disease and identify targets for effective repair.

Main Methods:

  • Review of preclinical and clinical data on Hedgehog pathway involvement in liver injury.
  • Analysis of the liver's conserved wound healing response.
  • Exploration of therapeutic strategies targeting the Hedgehog pathway.

Main Results:

  • The Hedgehog pathway is critically involved in regulating the liver's response to various forms of injury.
  • Preclinical and clinical evidence supports the Hedgehog pathway as a key regulator in liver disease.
  • Optimizing pathways crucial for liver repair may offer general benefits for liver disease outcomes.

Conclusions:

  • The Hedgehog pathway is a promising therapeutic target for liver disease.
  • Modulating Hedgehog pathway activity could lead to improved outcomes for patients with liver injury and cirrhosis.
  • Further research into the Hedgehog pathway's role is essential for developing effective liver disease treatments.