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ASK family in cardiovascular biology and medicine

Tingting Liu1, Huanjiao Jenny Zhou2, Wang Min3

  • 1Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Advances in Biological Regulation
|November 7, 2017
PubMed

Insights

Cardiovascular disease is a leading cause of death. This review explores how Apoptosis signal-regulating kinase 1 (ASK1) impacts cardiovascular health and discusses new therapies targeting the ASK1 pathway.

Area of Science:

  • Cardiovascular Biology
  • Molecular Signaling
  • Cellular Pathophysiology

Background:

  • Cardiovascular disease (CVD) represents a significant global health burden.
  • Mitogen-activated protein kinase (MAPK) signaling pathways are integral to cardiovascular pathophysiology.
  • Apoptosis signal-regulating kinase (ASK) family members (ASK1, ASK2, ASK3) are key regulators within MAPK cascades, activated by cellular stress.

Purpose of the Study:

  • To elucidate the role of ASK1 in cardiovascular disease.
  • To review novel therapeutic strategies targeting the ASK1 signaling pathway for cardiovascular conditions.

Main Methods:

  • Literature review of studies on ASK1 and cardiovascular disease.
  • Analysis of ASK1's involvement in cellular functions relevant to CVD (survival, proliferation, inflammation, apoptosis).
  • Exploration of therapeutic interventions modulating ASK1 signaling.

Main Results:

  • ASK1 is a critical MAPKKK extensively studied for its regulatory functions.
  • ASK1 influences cell survival, proliferation, inflammation, and apoptosis, all relevant to cardiovascular pathophysiology.
  • The ASK1 pathway presents potential therapeutic targets for cardiovascular diseases.

Conclusions:

  • ASK1 plays a pivotal role in the molecular mechanisms underlying cardiovascular disease.
  • Targeting the ASK1 pathway offers promising avenues for novel cardiovascular therapeutic strategies.

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