Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurodatascience: Past, Present, and Future.

Data science in science·2026
Same author

Integrating Dimensional Personality and Autistic Traits to Predict Suicidal Ideation, Suicide Attempts, and Nonsuicidal Self-Injury in Autistic Adults.

Autism research : official journal of the International Society for Autism Research·2026
Same author

A scalable reinforcement learning framework inspired by hippocampal memory mechanisms for efficient contextual and sequential decision making.

Scientific reports·2025
Same author

Chronic Pb<sup>2+</sup> Exposure Causes Hippocampal Network Hypersynchrony, Absence Seizures, and Sensorimotor Deficits.

bioRxiv : the preprint server for biology·2025
Same author

Methods for Brain Connectivity Analysis with Applications to Rat Local Field Potential Recordings.

Entropy (Basel, Switzerland)·2025
Same author

Constructs across a hierarchical, dimensional model of psychopathology show differential associations with social and general cognitive ability.

PloS one·2025
Same journal

Prenatal Exposure to High- but Not Low-Molecular-Weight Poly(I:C) Produces Selective Sociability Deficits in Offspring.

Behavioural brain research·2026
Same journal

Understanding vulnerability through variability: a longitudinal twin study linking sex differences in neurodiversity, neurodevelopment and X-linked genetic mechanisms.

Behavioural brain research·2026
Same journal

Hippocampal plasticity predicts behavioral lateralization and stress resilience in laying hen chicks.

Behavioural brain research·2026
Same journal

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.

Behavioural brain research·2026
Same journal

Bacopa-enriched formulation enhances memory and synaptic plasticity in a rat model of vascular dementia.

Behavioural brain research·2026
Same journal

Prior exposure to methylphenidate attenuates ethanol-induced conditioned place preference in zebrafish.

Behavioural brain research·2026
See all related articles

Related Experiment Video

Updated: Feb 19, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

17.0K

Nonspatial sequence coding varies along the CA1 transverse axis.

Chi-Wing Ng1, Gabriel A Elias1, Judith S A Asem1

  • 1Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.

Behavioural Brain Research
|November 7, 2017
PubMed
Summary
This summary is machine-generated.

Researchers found that neurons in the CA1 region of the hippocampus code for odor sequences differently along its axis. This sequence coding was highest in intermediate CA1, suggesting a specific role for this region in nonspatial memory.

Keywords:
ElectrophysiologyEpisodic memoryHippocampusLateral entorhinal cortexMedial entorhinal cortexProximodistal axisRatsSequence memoryTemporal context

More Related Videos

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.4K
Examining Local Network Processing using Multi-contact Laminar Electrode Recording
13:40

Examining Local Network Processing using Multi-contact Laminar Electrode Recording

Published on: September 8, 2011

13.2K

Related Experiment Videos

Last Updated: Feb 19, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

17.0K
Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.4K
Examining Local Network Processing using Multi-contact Laminar Electrode Recording
13:40

Examining Local Network Processing using Multi-contact Laminar Electrode Recording

Published on: September 8, 2011

13.2K

Area of Science:

  • Neuroscience
  • Memory Research
  • Hippocampal Function

Background:

  • The hippocampus is crucial for episodic memory, including memory for event sequences.
  • Previous research suggests distinct information processing along the CA1 region's distal-to-proximal axis.
  • Odor information is hypothesized to be more represented distally, while spatial information is more represented proximally.

Purpose of the Study:

  • To investigate how neural sequence coding in the dorsal CA1 region varies along its distal-to-proximal axis.
  • To determine if nonspatial sequence memory representation aligns with known gradients of sensory or spatial information processing.

Main Methods:

  • Neural activity was recorded in the CA1 region of rats performing a nonspatial odor sequence memory task.
  • Neurons were analyzed for differential firing patterns related to odor sequence (sequence cells).
  • Data were segmented into four sections along the distal-to-proximal axis of dorsal CA1.

Main Results:

  • Sequence cell coding was found across the recorded CA1 extent but was significantly higher in intermediate CA1.
  • Intermediate CA1 showed increased magnitude of sequence coding and sequential information content.
  • Spatial coding, indicated by place fields, was more strongly represented in the proximal CA1 section, consistent with prior studies.

Conclusions:

  • Nonspatial sequence memory coding is not uniform along the CA1 transverse axis.
  • The distribution of sequence coding does not strictly follow stimulus modality or spatial selectivity gradients.
  • The enhanced sequence coding in intermediate CA1 may relate to convergent input from lateral and medial entorhinal regions.