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A 3-year observation of testosterone deficiency in Chinese patients with chronic heart failure

Ying Han1, Weiju Sun2, Guizhi Sun1

  • 1Cardiovascular Department, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Oncotarget
|November 8, 2017
PubMed

Insights

Low testosterone levels in Chinese men with chronic heart failure (CHF) are linked to worse cardiac function, higher readmission rates, and increased mortality. This study highlights the importance of assessing testosterone in CHF patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Men's Health

Background:

  • Testosterone deficiency is a known factor contributing to adverse outcomes in men with chronic heart failure (CHF) in Western populations.
  • The association between low testosterone and mortality/readmission rates in Chinese CHF patients remains understudied.

Purpose of the Study:

  • To investigate the relationship between testosterone levels and clinical outcomes in Chinese men with CHF.
  • To determine if low free testosterone (FT) is associated with increased mortality and readmission in this cohort.

Main Methods:

  • 167 Chinese men with CHF were evaluated for total testosterone (TT) and free testosterone (FT) levels.
  • Patients were categorized into low testosterone (LT) and normal testosterone (NT) groups.
  • Clinical data and outcomes, including cardiac function, etiology, comorbidity, readmission rates, and mortality, were assessed over a minimum 3-year follow-up.

Main Results:

  • The LT group exhibited poorer cardiac function and a higher prevalence of ischemic etiology and comorbidities compared to the NT group.
  • Readmission rates were significantly higher in the LT group (3.32 ± 1.66) versus the NT group (1.57 ± 0.89).
  • Deficiencies in FT levels were strongly associated with increased mortality (Hazard Ratio = 6.301, P < .0001).

Conclusions:

  • Low free testosterone is a significant predictor of increased mortality in Chinese men with chronic heart failure.
  • Testosterone deficiency is associated with worse cardiac function and higher readmission rates in this population.
  • Routine assessment of testosterone levels may be beneficial for managing Chinese men with CHF.

Keywords:
chronic heart failuremortalityreadmissiontestosterone deficiency

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