Related Experiment Video

Updated: Feb 19, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

15.2K

Glutathione peroxidases as oncotargets

Yang Jiao1, Yirong Wang2, Shanchun Guo3

  • 1Department of Stomatology, PLA Army General Hospital, Beijing, P.R. China.

Oncotarget
|November 8, 2017
PubMed

Insights

Oxidative stress disrupts cellular balance, impacting cancer. Glutathione peroxidases (GPxs) enzymes combat this damage, playing key roles in cancer development and progression. Understanding GPxs may improve cancer treatments.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Oxidative stress arises from an imbalance between reactive oxygen species and antioxidant defenses.
  • This imbalance is implicated in various cellular processes, including cancer cell survival and proliferation.
  • Glutathione peroxidases (GPxs) are crucial antioxidant enzymes that protect against oxidative damage.

Purpose of the Study:

  • To review recent advancements in understanding the roles of glutathione peroxidases (GPxs) in cancer.
  • To highlight the significance of GPxs in different stages of carcinogenesis.
  • To explore the potential of GPxs research in developing novel cancer therapies.

Main Methods:

  • Literature review of studies on GPxs and cancer.
  • Analysis of the enzymatic activity of GPxs in relation to oxidative stress.
  • Examination of the involvement of GPxs in cancer cell biology.

Main Results:

  • GPxs are essential for reducing hydrogen peroxide and lipid hydroperoxides.
  • Eight sub-members of GPxs identified in humans exhibit diverse roles.
  • Numerous publications confirm the significant involvement of GPxs in various stages of cancer development.

Conclusions:

  • GPxs play critical roles in carcinogenesis, influencing cancer cell behavior.
  • Further mechanistic insights into GPxs functions are needed.
  • Enhanced understanding of GPxs could lead to improved cancer treatment strategies.
Keywords:
carcinogenesisdrug targetglutathione peroxidasesoxidative stressreactive oxygen species

More Related Videos

Author Spotlight: Innovating Thiol Quantification and Biomarker Detection for Oxidative Stress Research03:35

Author Spotlight: Innovating Thiol Quantification and Biomarker Detection for Oxidative Stress Research

Published on: June 28, 2024

2.1K
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

2.0K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.1K
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
1.0K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
21.5K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
24