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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Autophagic Cell Death01:18

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Related Experiment Video

Updated: Feb 19, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Autophagy dysfunction in autoinflammatory diseases.

Yichao Hua1, Min Shen1, Christine McDonald2

  • 1Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Journal of Autoimmunity
|November 8, 2017
PubMed
Summary
This summary is machine-generated.

Autoinflammatory diseases involve innate immune system dysregulation. Genetic variants impairing autophagy worsen inflammation, suggesting autophagy as a potential therapeutic target for these conditions.

Keywords:
Autoinflammatory diseasesAutophagyFamilial mediterranean feverHyperimmunoglobulinemia D and periodic fever syndromeNOD2-associated diseasesTNF receptor-associated periodic syndrome

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Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Autoinflammatory diseases (AUIDs) are genetic disorders marked by recurring inflammation due to faulty innate immune responses.
  • Autophagy, a cellular process for clearing damaged components, is increasingly recognized for its role in regulating inflammation.

Purpose of the Study:

  • To review molecular mechanisms in AUIDs, focusing on genetic variants and the role of autophagy.
  • To explore how impaired autophagy contributes to the pathogenesis of AUIDs.

Main Methods:

  • Review of existing literature on genetic variants in AUIDs.
  • Analysis of molecular pathways, including innate immune signaling and autophagy.
  • Summary of evidence linking genetic variants to autophagic dysfunction.

Main Results:

  • Specific AUIDs like FMF, TRAPS, HIDS, and NOD2-associated diseases share altered molecular mechanisms.
  • Genetic variants in AUIDs can directly activate inflammatory pathways.
  • Evidence suggests these variants also impair autophagy, indirectly amplifying inflammation.

Conclusions:

  • Dysregulated autophagy is implicated in the pathogenesis of various AUIDs.
  • Impairment of autophagy occurs through diverse mechanisms driven by disease-associated variants.
  • Autophagy represents a promising novel therapeutic target for autoinflammatory diseases.