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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
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Therapeutic HPV vaccines
Gemma Hancock1, Karin Hellner2, Lucy Dorrell3
1Nuffield Department of Medicine, University of Oxford and Oxford NIHR Biomedical Research Centre, NDM Research Building, Old Road Campus, Headington, Oxford, UK.
Best Practice & Research. Clinical Obstetrics & Gynaecology
|November 8, 2017
Summary
Therapeutic human papillomavirus (HPV) vaccines aim to boost immune responses to clear existing infections and pre-cancerous lesions. This review explores developing strategies for treating HPV-associated cancers and conditions.
Area of Science:
- Oncology
- Immunology
- Virology
Background:
- High-risk human papillomavirus (HPV) is essential for cervical and anogenital cancers, causing over 250,000 deaths yearly.
- Current prophylactic HPV vaccines do not clear established infections or preinvasive lesions.
- Spontaneous regression of cervical dysplasia highlights the potential for immune-boosting therapies.
Purpose of the Study:
- To review therapeutic HPV vaccine strategies under development.
- To discuss approaches for treating HPV-associated lesions and malignancies.
Main Methods:
- Literature review of therapeutic HPV vaccine research.
- Analysis of strategies focusing on cell-mediated immunity.
Main Results:
- Therapeutic vaccines aim to generate cell-mediated immunity, distinct from prophylactic vaccines.
- Various therapeutic vaccine approaches are in development for HPV-associated conditions.
Conclusions:
- Therapeutic HPV vaccines offer a promising strategy to complement prophylactic vaccines.
- Boosting host immunity could significantly reduce HPV-related morbidity and mortality.
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