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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study.

William Gillespie1, Neil Marya2, Julien Fahed3

  • 1Department of Medicine, University of Massachusetts School of Medicine, 55 Lake Avenue North, Worcester, MA 01604, USA.

Gastroenterology Research and Practice
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Inflammatory bowel disease (IBD) patients contract Clostridium difficile infections (CDI) younger and often without typical risk factors. Those with CDI more frequently need biologic therapy and show increased extraintestinal manifestations.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Epidemiology

Background:

  • Inflammatory bowel disease (IBD) encompasses chronic conditions like Crohn's disease and ulcerative colitis.
  • Clostridium difficile infection (CDI) is a significant concern in healthcare settings, particularly for vulnerable populations.
  • Understanding CDI epidemiology in IBD patients is crucial for effective management and prevention.

Purpose of the Study:

  • To investigate the epidemiology of Clostridium difficile infections (CDI) in patients with inflammatory bowel disease (IBD).
  • To identify risk factors associated with CDI development in the IBD population.
  • To compare characteristics of IBD patients with and without CDI.

Main Methods:

  • Retrospective study analyzing charts of 654 IBD patients meeting inclusion criteria.
  • Patients divided into two cohorts: those with and without a prior CDI diagnosis.
  • Statistical analyses included Pearson's chi-squared and two-sample t-tests.

Main Results:

  • The incidence of CDI among IBD patients was 6.7%.
  • CDI prevalence was similar in Crohn's disease (49%) and ulcerative colitis (51%) patients.
  • IBD patients acquired CDI at a mean age of 42.7 years, with community acquisition (56%) more common than healthcare-associated (28%).
  • Traditional risk factors like prior antibiotic (30%) and steroid use (16%) were less frequent.
  • IBD patients with CDI were more likely to require biologic therapy (57% vs. 37%) and have extraintestinal manifestations (43% vs. 28%).

Conclusions:

  • IBD patients are susceptible to CDI at a younger age and often lack traditional risk factors.
  • IBD patients with CDI demonstrated increased need for biologic therapy.
  • Higher rates of extraintestinal manifestations were observed in IBD patients with CDI.