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An Open-Source Normothermic Perfusion System Designed for Research Scientists

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Opportunities for Therapeutic Intervention During Machine Perfusion.

Negin Karimian^1,2, Heidi Yeh¹

¹Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Current Transplantation Reports

|November 8, 2017

Summary

Ex vivo machine perfusion (MP) extends organ preservation and viability, enabling the use of more donor organs. MP also serves as a platform for therapeutic interventions to improve organ quality before transplantation.

Keywords:

ex-situ machine perfusion ischemia reperfusion injury preservation transplantation

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Area of Science:

Transplantation Science
Regenerative Medicine
Organ Preservation Technology

Background:

Significant organ donor shortage necessitates innovative preservation and improvement strategies.
Conventional static cold storage has limitations in extending organ viability and usability.
Ex vivo machine perfusion (MP) offers a promising alternative for organ preservation and assessment.

Purpose of the Study:

To review the current applications of ex vivo machine perfusion (MP) in organ transplantation.
To highlight MP's role in organ preconditioning and therapeutic interventions.
To discuss MP's potential in expanding the donor organ pool.

Main Methods:

Review of existing literature on ex vivo machine perfusion for organ transplantation.
Analysis of studies investigating MP for organ preservation and therapeutic applications.
Focus on pre-transplant interventions facilitated by MP.

Main Results:

MP enables longer organ preservation compared to static cold storage.
MP facilitates the utilization of organs previously considered unsuitable for transplantation.
Experimental studies demonstrate MP's efficacy in reducing ischemia reperfusion injury through various therapeutic agents, including mesenchymal stem cells (MSCs).

Conclusions:

Ex vivo machine perfusion represents a significant advancement in organ transplantation.
MP serves as a platform for novel therapeutic strategies in organ medicine.
This technology is poised to transform the field of organ transplantation and tissue engineering.