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Fecal micro RNA Isolation
Published on: October 28, 2020
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MicroRNA in gastrointestinal cell signalling.
Priyanka Mishra1, Divya Singh2, Lilly Ganju1
1Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
Inflammopharmacology
|November 8, 2017
Summary
Gut health relies on cell signaling pathways and microflora. MicroRNAs regulate these pathways, balancing gut tolerance and inflammation, which is crucial for preventing gut inflammation.
Area of Science:
- Gastroenterology and Molecular Biology
- Focuses on the intricate mechanisms governing gut health and inflammation.
Background:
- The gut is a vital organ whose homeostasis is maintained by cell signaling pathways and commensal microflora.
- These factors influence pathological, physiological, and immunological parameters essential for gut health and preventing inflammation.
Purpose of the Study:
- To review the critical role of intracellular signaling pathways in maintaining gut homeostasis.
- To elucidate the regulatory function of specific microRNAs in these pathways and their impact on gut inflammation.
Main Methods:
- Literature review of studies on gut homeostasis, cell signaling, and microRNAs.
- Analysis of the interplay between microRNAs, signaling pathways, and gut immune responses.
Main Results:
- Intracellular signaling pathways are key regulators of gut homeostasis.
- MicroRNAs play a significant role in modulating these pathways, influencing the balance between tolerance and inflammation.
Conclusions:
- Cell signaling pathways are indispensable for maintaining gut health.
- MicroRNAs are crucial regulators in this process, offering potential therapeutic targets for gut inflammation.
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