Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microchimerism in the human brain, quantitative assessment and single nuclei profiling establish cell types and diversity.

bioRxiv : the preprint server for biology·2026

Same author

The relationship between infant feeding types, gut microbiome, intestinal inflammation, and neurodevelopment in a neonatal piglet model.

JPEN. Journal of parenteral and enteral nutrition·2025

Same author

Repeated Administration of Pharmaceutical-Grade Medium-Chain Triglycerides, a Common Pharmacologic Excipient, Confers Dose-Dependent Toxicity by the Intraperitoneal but Not Oral Route in Mice.

Journal of the American Association for Laboratory Animal Science : JAALAS·2025

Same author

Physiological and injury-induced microglial dynamics across the lifespan.

Cell reports·2025

Same author

Repeated administration of pharmaceutical-grade medium chain triglycerides, a common pharmacologic excipient, confers dose-dependent toxicity by the intraperitoneal but not oral route in mice.

bioRxiv : the preprint server for biology·2024

Same author

Unboxing "Omics" in Glial Biology to Understand Neurological Disease.

Glia·2024

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Correction to: Neuroimmune Response in Ischemic Preconditioning.

Ashley McDonough¹, Jonathan R Weinstein²

¹Department of Neurology, University of Washington, Seattle, WA, USA.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics

|November 8, 2017

Summary

Ischemic preconditioning (IPC) offers neuroprotection against brain ischemia by engaging innate immune pathways and cellular crosstalk. Understanding these mechanisms may reveal novel therapeutic targets for stroke recovery.

Keywords:

Interferon Ischemic preconditioning Microglia Progenitors Stroke Toll-like receptor

More Related Videos

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

Related Experiment Videos

Last Updated: Feb 19, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

Area of Science:

Neuroscience
Immunology
Cell Biology

Background:

Ischemic preconditioning (IPC) is a neuroprotective phenomenon where brief ischemia confers tolerance to subsequent ischemic events.
IPC involves complex cellular, molecular, and immune responses within the central nervous system.

Purpose of the Study:

To explore the molecular and cellular mediators of ischemic preconditioning.
To understand the role of neuroinflammation and immune cells in IPC-induced neuroprotection.
To identify potential therapeutic targets for stroke intervention.

Main Methods:

Review of existing research on IPC mechanisms.
Analysis of molecular signaling pathways (e.g., Toll-like receptors, interferons).
Investigation of cellular components including microglia, astrocytes, neurons, and peripheral immune cells.

Main Results:

IPC utilizes innate immune signaling and cytokine release to modulate neuroinflammation.
Cross-talk between microglia, astrocytes, and neurons is crucial for neuroprotection.
The role of peripheral immune cells and neural progenitor cells in IPC is an active area of research.

Conclusions:

Mechanistic insights into IPC can lead to improved clinical applications.
Understanding IPC mediators may reveal novel therapeutic strategies for stroke.
Further research into cellular and molecular players is essential for harnessing IPC's neuroprotective potential.