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TRIM proteins in blood cancers

Lisa J Crawford1, Cliona K Johnston1, Alexandra E Irvine2

  • 1Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Journal of Cell Communication and Signaling
|November 8, 2017
PubMed

Insights

Tripartite motif (TRIM) proteins are crucial E3 ligases regulating cellular functions. This review highlights their significant involvement in the development and progression of various blood cancers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Post-translational modification via ubiquitination is vital for cellular processes.
  • E3 ligases, including the tripartite motif (TRIM) family, dictate ubiquitination specificity.
  • Dysregulation of TRIM proteins is linked to diverse pathologies.

Purpose of the Study:

  • To review the role of tripartite motif (TRIM) proteins in hematological malignancies.
  • To consolidate current understanding of TRIM protein involvement in blood cancers.

Main Methods:

  • Literature review of scientific articles and research papers.
  • Focus on studies investigating TRIM proteins and their association with blood cancers.

Main Results:

  • TRIM proteins are a large subfamily of E3 ligases with critical cellular functions.
  • Evidence links TRIM protein dysregulation to various diseases, particularly blood cancers.

Conclusions:

  • TRIM proteins represent a significant area of research in hematologic oncology.
  • Further investigation into TRIM proteins may reveal novel therapeutic targets for blood cancers.
Keywords:
E3 ligaseLeukaemiaLymphomaMultiple myelomaTRIM proteinsUbiquitin

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