Related Experiment Video

Updated: Feb 19, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Relationship between left ventricular dyssynchrony and scar burden in the genesis of ventricular tachyarrhythmia

Saurabh Malhotra1, Deepak K Pasupula2, Ravi K Sharma3

  • 1Division of Cardiovascular Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|November 8, 2017
PubMed

Insights

Left ventricular dyssynchrony (LVD) significantly predicts ventricular tachyarrhythmia (VT) in patients with low ejection fraction. Combining LVD with myocardial scar burden accurately identifies the majority of VT events.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Electrophysiology

Background:

  • Left ventricular ejection fraction (LVEF) has limited predictive power for ventricular tachyarrhythmia (VT).
  • Left ventricular dyssynchrony (LVD) and myocardial scar burden are individually linked to VT.
  • The combined impact of LVD and scar on VT genesis remains underexplored.

Purpose of the Study:

  • To investigate the relationship between LVD and myocardial scar characteristics in predicting VT.
  • To evaluate the predictive value of LVD for VT in patients with reduced LVEF.
  • To assess the combined predictive power of LVD and scar burden for VT events.

Main Methods:

  • Retrospective analysis of 183 patients receiving an implantable cardioverter-defibrillator (ICD) for primary prevention.
  • Gated single-photon emission computed tomography (GSPECT) myocardial perfusion scans used to assess LVD via phase analysis.
  • VT occurrence determined through ICD interrogations and medical records.

Main Results:

  • LVD was present in 74% of patients; 98% of those experiencing VT had LVD.
  • Patients without LVD demonstrated significantly better survival free of VT (HR: 4.90, P < 0.0001).
  • The combination of LVD and myocardial scar > 6% of LV myocardium accounted for 83% of VT events.

Conclusions:

  • LVD assessment by GSPECT is a strong predictor of incident VT in patients with low LVEF.
  • The combined presence of LVD and significant myocardial scar burden effectively predicts the majority of VT events.
Abstract

Keywords:
Heart failureleft ventricular dyssynchronyventricular tachyarrhythmia

More Related Videos

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

2.0K
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

15.4K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
540
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.4K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
654
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
658