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Published on: September 26, 2025
Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin
Anna Adamska-Bartłomiejczyk1, Attila Borics2, Csaba Tömböly2
1Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
Abstract:
Three novel morphiceptin analogs, in which Pro in position 2 and/or 4 was replaced by cis-4-aminoproline connected with the preceding amino acid through the primary amino group, were synthesized. The opioid receptor affinities, functional assay results, enzymatic degradation studies and experimental and in silico structural analysis of such analogs are presented. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
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