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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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γ-AApeptides as a New Strategy for Therapeutic Development.

Alekhya Nimmagadda1, Yan Shi1, Jianfeng Cai1

  • 1Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, United States.

Current Medicinal Chemistry
|November 8, 2017
PubMed
Summary

New gamma-AApeptides are versatile peptidomimetics with broad biomedical potential. These molecules show promise as drug carriers, anti-HIV agents, antimicrobials, anti-cancer therapies, and treatments for Alzheimer's disease.

Keywords:
anti-Aβ aggregationanti-HIV activityanticancer activityantimicrobial activitypeptidomimeticsstructuresγ-AApeptides.

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Area of Science:

  • Medicinal Chemistry
  • Biotechnology
  • Drug Discovery

Background:

  • Peptidomimetics offer advantages over natural peptides, including resistance to degradation.
  • Gamma-AApeptides represent a novel class of peptidomimetics with tunable properties.
  • Diverse biological applications are being explored for peptidomimetic structures.

Purpose of the Study:

  • To review the biological potential and diverse applications of gamma-AApeptides.
  • To highlight gamma-AApeptides as promising candidates for various therapeutic areas.
  • To showcase the versatility of gamma-AApeptides in biomedical research.

Main Methods:

  • Development of a new class of peptidomimetics: gamma-AApeptides.
  • Exploration of chemical diversity and functional group introduction.
  • Evaluation of biological activities through various assays and models.

Main Results:

  • Gamma-AApeptides demonstrate cell membrane permeability, suitable for drug delivery.
  • Specific binding to HIV RNA suggests potential as anti-HIV agents.
  • Mimicry of host-defense peptides confers broad-spectrum antimicrobial activity.
  • Anti-cancer potential shown through tumor imaging and disruption of p53/DNA interactions.
  • Inhibition of Aβ peptide aggregation indicates promise for Alzheimer's disease treatment.

Conclusions:

  • Gamma-AApeptides are a highly promising class of peptidomimetics with broad therapeutic potential.
  • Their unique properties enable applications in drug delivery, infectious diseases, oncology, and neurodegenerative disorders.
  • Further research into gamma-AApeptides could lead to novel treatments for various diseases.