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Updated: Feb 19, 2026
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
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Influence of Implants Composition on Melatonin Release from Ethylcellulose Matrix
Emilie Duffau1, Etienne Harte1, Jean Toutain2
1CBMN, UMR 5248, University Bordeaux, CNRS, Bordeaux INP, 33600 Pessac, France.
Current Drug Delivery
|November 8, 2017
Summary
This study investigated melatonin release from ethylcellulose implants, revealing a micellar transport mechanism. Two distinct drug release regimes were identified, influenced by polymer structure and porosity.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Melatonin release kinetics from ethylcellulose matrices across all compositions remain uninvestigated.
- Understanding these release profiles is crucial for developing effective drug delivery systems.
Purpose of the Study:
- To comprehensively study melatonin release from ethylcellulose implants, examining kinetic and structural influences.
- To explore the impact of varying melatonin loading on release behavior.
Main Methods:
- Fabrication of cylindrical implants with diverse Melatonin:Ethylcellulose ratios.
- In vitro dissolution testing in CTAB micellar solutions.
- Confocal Raman spectroscopy for 2D imaging and FT-IR/Karl-Fisher for hydration studies.
Main Results:
- Radial drug leakage observed across all implant compositions.
- Apparent diffusion coefficients for melatonin ranged from 2-6 x 10^-12 cm²/s, dependent on ethylcellulose content.
- Non-monotonous variation in characteristic drug delivery time identified, with two distinct release regimes.
Conclusions:
- Melatonin exhibits micellar transport during release.
- Two release regimes are explained by polymer barrier effects, initial porosity, and domain connectivity.
