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Related Experiment Video

Updated: Feb 19, 2026

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High-throughput gadobutrol-enhanced CMR: a time and dose optimization study.

Tommaso D'Angelo1,2, Chrysanthos Grigoratos3,4, Silvio Mazziotti5

  • 1Department of Biomedical Sciences and Morphological and Functional Imaging, G. Martino University Hospital Messina, Via Consolare Valeria, 1, 98100, Messina, Italy. tommasodang@gmail.com.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|November 8, 2017
PubMed
Summary

A new cardiovascular magnetic resonance (CMR) protocol using gadobutrol allows for reduced contrast agent doses and examination time. This optimized approach maintains diagnostic accuracy for left ventricular function and scar imaging, lowering costs and patient exposure.

Keywords:
Cardiovascular magnetic resonanceDose optimizationGadobutrolTime optimization

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Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Radiology

Background:

  • Reducing time and contrast agent doses are key goals for cost-efficient cardiovascular magnetic resonance (CMR) imaging.
  • Limited data exists on evaluating left ventricular (LV) function post-gadobutrol and defining optimal doses for scar imaging.
  • This study aimed to optimize contrast-enhanced CMR (CE-CMR) protocols using gadobutrol.

Purpose of the Study:

  • To evaluate the feasibility of assessing LV function after gadobutrol injection.
  • To determine the lowest effective gadobutrol dose for high-quality scar imaging.
  • To establish an optimized CE-CMR protocol for gadobutrol administration.

Main Methods:

  • Prospective, randomized, single-blind cross-over study in two patient populations.
  • Population 1: Assessed LV function (cine-imaging) before and after 0.1 mmol/kg gadobutrol.
  • Population 2: Evaluated late gadolinium enhancement (LGE) imaging at different gadobutrol doses (0.1 vs. 0.2 mmol/kg) and time delays.

Main Results:

  • Excellent correlation for LV function (stroke volume, ejection fraction) between pre- and post-contrast cine-imaging.
  • LV volumes (end-diastolic, end-systolic) were significantly larger post-contrast.
  • Optimal LGE image quality achieved at 10 min post-injection (0.1 mmol/kg) and 20 min (0.2 mmol/kg), with no significant difference in LGE quantification.

Conclusions:

  • A standardized CE-CMR protocol with 0.1 mmol/kg gadobutrol before cine-imaging and LGE at 10 min is feasible.
  • This fast, low-dose protocol offers comparable information to longer, higher-dose protocols.
  • The optimized protocol reduces examination time, costs, and contrast agent exposure.