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Aortic elasticity and carotid intima-media thickness in children with mitral valve prolapse

Elif Erolu1, Figen Akalın1, Nilüfer Çetiner1

  • 1Department of Pediatrics,Divisions of Pediatric Cardiology,Marmara University Faculty of Medicine,İstanbul,Turkey.

Cardiology in the Young
|November 8, 2017
PubMed

Insights

Mitral valve prolapse is a connective tissue disease that affects cardiac chambers and aortic elasticity. This may suggest a lower risk of atherosclerosis in patients with mitral valve prolapse.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Genetics

Background:

  • Mitral valve prolapse (MVP) is often associated with connective tissue disorders.
  • Understanding the cardiovascular implications of MVP is crucial for patient management.

Purpose of the Study:

  • To investigate cardiac and aortic dimensions and function in children with mitral valve prolapse.
  • To assess carotid intima-media thickness and brachial artery flow-mediated dilatation in MVP patients.

Main Methods:

  • Echocardiographic measurements of left ventricular and aortic dimensions, including strain and distensibility.
  • Calculation of aortic z-scores, stiffness index, and carotid intima-media thickness.
  • Flow-mediated dilatation assessment of the brachial artery.

Main Results:

  • Patients with MVP exhibited larger left ventricular and left atrial diameters, and aortic dimensions.
  • Increased aortic strain and distensibility, with decreased stiffness, were observed in the MVP group.
  • Classical MVP was associated with lower aortic strain and distensibility, and higher stiffness; carotid intima-media thickness was reduced.

Conclusions:

  • Mitral valve prolapse is a systemic connective tissue disease impacting cardiac chambers and aortic elasticity.
  • Reduced carotid intima-media thickness in MVP patients may indicate a lower risk of atherosclerosis.

Keywords:
Mitral valve prolapseaortic elasticitycarotid intima-media thicknesschildren

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