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Cerebrospinal fluid in the dementias.
Henrik Zetterberg1, Jonathan D Rohrer2, Jonathan M Schott2
1Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom.
Handbook of Clinical Neurology
|November 8, 2017
Summary
This review covers cerebrospinal fluid biomarkers for common dementias like Alzheimer disease and vascular dementia. It details established and emerging biomarkers for diagnosis and differentiating these neurocognitive disorders.
Area of Science:
- Neuroscience
- Neurology
- Biochemistry
Background:
- Alzheimer disease, vascular dementia, dementia with Lewy bodies, and frontotemporal dementia are leading causes of neurocognitive decline.
- Accurate diagnosis of dementia subtypes is challenging but crucial for effective management.
- Biomarkers offer objective measures to aid in the diagnosis and differentiation of these conditions.
Purpose of the Study:
- To review current cerebrospinal fluid (CSF) biomarkers for major dementia types.
- To provide an overview of established and emerging biomarkers.
- To discuss clinical utility and differential diagnostic applications of CSF biomarkers.
Main Methods:
- Literature review of established and emerging CSF biomarkers.
- Focus on tau and amyloid-beta related biomarkers.
- Analysis of clinical use and differential diagnostic aspects.
Main Results:
- Established CSF biomarkers primarily involve tau and amyloid-beta.
- Emerging biomarkers show promise for improved diagnostic accuracy.
- CSF biomarkers are valuable tools for differential diagnosis in dementia.
Conclusions:
- Cerebrospinal fluid biomarkers are essential for diagnosing and differentiating common neurocognitive disorders.
- Established biomarkers like tau and amyloid-beta are critical, with ongoing research into novel markers.
- Understanding the clinical application of these biomarkers aids in patient management and research.
Keywords:
Alzheimer's diseaseBiomarkersamyloidcerebrospinal fluiddementiadementia with Lewy bodiesfrontotemporal dementiatauvascular dementiaMore Related Videos
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