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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Assessment of the Rectum and Anus01:25

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Related Experiment Video

Updated: Feb 19, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
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Hirschsprung disease-Bowel function beyond childhood.

Tomas Wester1, Anna Löf Granström1

  • 1Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Seminars in Pediatric Surgery
|November 8, 2017
PubMed
Summary
This summary is machine-generated.

Hirschsprung disease, a congenital condition affecting the enteric nervous system, often leads to long-term bowel dysfunction into adulthood. While quality of life is impacted, education and occupation are generally unaffected.

Keywords:
Bowel functionConstipationFecal incontinenceHirschsprung diseaseQuality of lifeSoiling

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Area of Science:

  • Gastroenterology
  • Developmental biology
  • Pediatric surgery

Background:

  • Hirschsprung disease is a congenital disorder of the enteric nervous system, resulting in aganglionic segments of the distal colon.
  • Impaired bowel function is a known complication, with previous studies focusing primarily on short-term outcomes.

Purpose of the Study:

  • To review and synthesize current knowledge on bowel function outcomes in patients with Hirschsprung disease beyond childhood.
  • To assess the long-term impact of Hirschsprung disease on bowel function in adolescents and adults.

Main Methods:

  • Systematic review of controlled studies and relevant literature.
  • Analysis of data on bowel function, quality of life, education, and occupation in patients with Hirschsprung disease.

Main Results:

  • Bowel dysfunction, including constipation and fecal incontinence, persists into adolescence and adulthood in a significant proportion of patients.
  • Despite impaired bowel function, most patients adapt, and the disease has a limited impact on educational and occupational achievements.
  • Quality of life is negatively affected by bowel symptoms, though adaptation occurs.

Conclusions:

  • Hirschsprung disease has significant long-term consequences for bowel function and quality of life into adulthood.
  • While functional impairments are notable, educational and occupational trajectories are generally preserved, indicating patient adaptation.