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Oxidative stress induces renal failure: A review of possible molecular pathways

Habib Yaribeygi1,2, Farin R Farrokhi2, Ramin Rezaee3

  • 1Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Journal of Cellular Biochemistry
|November 8, 2017
PubMed

Insights

Oxidative stress significantly contributes to chronic kidney diseases by damaging cells and triggering harmful pathways. Understanding these mechanisms is key to developing new treatments for kidney disorders.

Area of Science:

  • Nephrology
  • Pathophysiology
  • Molecular Biology

Background:

  • Oxidative stress is implicated in numerous diseases, including chronic kidney diseases (CKD).
  • Free radicals cause cellular damage, activate signaling pathways, and induce systemic responses leading to kidney injury.

Purpose of the Study:

  • To review the literature on the effects of oxidative stress on the pathophysiology of chronic renal disorders.
  • To explore the molecular mechanisms by which free radicals induce CKD.

Main Methods:

  • Literature search of PubMed-Medline and Scopus databases.
  • Keywords used: oxidative stress, kidney, chronic kidney diseases, free radicals.
  • Focus on molecular mechanisms and pathways involved in oxidative stress-induced CKD.

Main Results:

  • Identified approximately 200 relevant articles.
  • Detailed nine key molecular pathways through which free radicals impact renal function.
  • Confirmed the significant role of oxidative stress in CKD pathophysiology.

Conclusions:

  • Oxidative stress plays a crucial role in the development and progression of chronic kidney diseases.
  • Understanding these molecular pathways may reveal novel therapeutic strategies for managing CKD.
Keywords:
chronic kidney diseasefree radicalskidneyoxidative stress

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