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Radiosensitivity of lymphocytes from patients with Alzheimer's disease
1Department of Ophthalmic Optics, University of Manchester Institute of Science and Technology, Great Britain.
Mutation Research
|January 1, 1989
Abstract:
The response after gamma-irradiation of lymphocytes from 8 patients with Alzheimer's disease (AD), 3 patients with Huntington's disease and 13 normal subjects to stimulation by phytohaemagglutinin (PHA) was assayed by incorporation of [3H]thymidine. The response of non-irradiated cells was found to be significantly lower in AD cells than in age-matched normals but not significantly lower in old normals than in young normals. However, the response of irradiated cells to PHA, expressed as a percentage of that in non-irradiated cells, was found to be similar in AD patients, young and old normals and in HD patients.