Association between CBR1 polymorphisms and NSCLC in the Chinese population
Yong Guo1, Yingying Shen1, Yongming Xia2
1Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.
Oncology Letters
|November 9, 2017
Summary
Genetic variations in Carbonyl reductase 1 (CBR1) single-nucleotide polymorphisms (SNPs) are linked to non-small cell lung cancer (NSCLC) risk in a Chinese population. Specifically, the CBR1 rs3787728 polymorphism influences susceptibility to lung cancer, particularly squamous-cell carcinoma and adenocarcinoma.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Carbonyl reductase 1 (CBR1) is implicated in cellular processes like apoptosis and carcinogenesis, and is overexpressed in lung tumors.
- Gene polymorphisms, including single-nucleotide polymorphisms (SNPs), are increasingly recognized for their role in cancer susceptibility.
- Non-small cell lung cancer (NSCLC) is a major global health concern, necessitating research into its genetic underpinnings.
Purpose of the Study:
- To investigate the association between CBR1 SNPs (rs3787728 and rs2835267) and the risk of developing NSCLC in a Chinese population.
- To determine if specific genotypes of CBR1 rs3787728 and rs2835267 correlate with increased or decreased susceptibility to NSCLC.
- To explore potential differences in these associations based on patient sex and NSCLC subtype (squamous-cell carcinoma and adenocarcinoma).
Main Methods:
- Case-control study design involving NSCLC patients and healthy controls from a Chinese population.
- Genotyping of CBR1 SNPs rs3787728 and rs2835267 using appropriate molecular techniques.
- Statistical analysis, including odds ratios (OR) and 95% confidence intervals (CI), to assess the association between SNPs and NSCLC risk, stratified by sex and histology.
Main Results:
- The allele frequency of CBR1 rs3787728 showed a significant difference between NSCLC patients and controls (OR=1.209, P=0.0349), particularly in males (OR=1.278, P=0.0358).
- The rs3787728 T/T genotype was associated with an increased risk of NSCLC (OR=1.382, P=0.037) and lung squamous-cell carcinoma (OR=1.537, P=0.0395).
- The rs3787728 C/C genotype was linked to a decreased risk of adenocarcinoma in males (OR=0.633, P=0.0348), while rs2835267 showed no significant association with NSCLC subtypes.
Conclusions:
- Genetic polymorphisms in CBR1 rs3787728 are significantly associated with susceptibility to NSCLC in the studied Chinese population.
- The rs3787728 polymorphism may play a role in the risk of developing specific NSCLC subtypes, such as squamous-cell carcinoma and adenocarcinoma.
- Further research is warranted to elucidate the functional mechanisms underlying CBR1's role in NSCLC pathogenesis and its potential as a biomarker.
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