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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Updated: Feb 19, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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Oxidative Stress in Stem Cell Aging.

Feng Chen1, Yingxia Liu1, Nai-Kei Wong1

  • 11 State Key Discipline of Infectious Diseases and Chemical Biology Laboratory for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.

Cell Transplantation
|November 9, 2017
PubMed
Summary
This summary is machine-generated.

Stem cell aging involves losing self-renewal and differentiation abilities due to oxidative stress. Enhancing antioxidant capacity may improve stem cell therapies for aging diseases.

Keywords:
agingoxidative stresssignaling pathwaystem celltransplantation

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Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Stem cell aging is characterized by diminished self-renewal and differentiation capabilities.
  • Oxidative stress and damage to cellular macromolecules are key contributors to stem cell aging.
  • Impaired cellular repair and metabolic homeostasis due to reactive oxygen species drive aging pathways.

Purpose of the Study:

  • To explore the molecular mechanisms of stem cell aging, focusing on oxidative stress.
  • To discuss the role of oxidative stress in stem cell aging at the molecular level.
  • To examine strategies for enhancing antioxidant capacity for cytoprotection in stem cell transplantation.

Main Methods:

  • Review of current literature on stem cell aging and oxidative stress.
  • Analysis of molecular pathways involved in stem cell aging.
  • Exploration of cytoprotective strategies through antioxidant enhancement.

Main Results:

  • Oxidative stress significantly contributes to stem cell aging by damaging cellular components and disrupting homeostasis.
  • Insufficient antioxidant reserves exacerbate oxidative damage, leading to functional depletion of stem cells.
  • Enhancing endogenous antioxidant capacity presents a potential therapeutic strategy for stem cell transplantation.

Conclusions:

  • Oxidative stress is a critical factor in stem cell aging, impacting molecular signaling and cellular function.
  • Targeting oxidative stress pathways offers a promising avenue for developing therapies for aging-related diseases.
  • Improving stem cell antioxidant capacity could enhance the efficacy of clinical transplantation therapies.