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Reproducible research practices are underused in systematic reviews of biomedical interventions

Matthew J Page1, Douglas G Altman2, Larissa Shamseer3

  • 1School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria 3004, Australia.

Journal of Clinical Epidemiology
|November 9, 2017
PubMed
Abstract

Insights

Reproducible research practices are underused in biomedical systematic reviews (SRs). Improving these practices enhances accuracy and allows for reanalysis of SR data.

Area of Science:

  • Biomedical Research
  • Systematic Reviews
  • Meta-Analysis

Background:

  • Reproducible research practices are crucial for verifying scientific findings.
  • Their adoption in systematic reviews (SRs) allows for independent reanalysis and error detection.

Purpose of the Study:

  • To evaluate the utilization of reproducible research practices in biomedical SRs.
  • To identify factors associated with the use of these practices.

Main Methods:

  • A random sample of 110 SRs focusing on therapeutic interventions and published in MEDLINE in February 2014 were analyzed.
  • Data on reproducible research practices were extracted using a 26-item form.
  • Association with Cochrane reviews and PRISMA statement use was explored.

Main Results:

  • Only 65% of SRs provided sufficient detail to recreate all meta-analytic effects.
  • Reproducible research practices were more common in Cochrane reviews (94%) than non-Cochrane reviews (54%).
  • Access to datasets and statistical code was reported in only 30% of SRs.

Conclusions:

  • Reproducible research practices are underutilized in SRs of biomedical interventions.
  • Increased adoption of these practices can improve the reliability and reanalyzability of SR findings.
Keywords:
Data sharingMethodologyQualityReportingReproducibilitySystematic reviews

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